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PROTOCOL TO ASSESS ASBESTOS-RELATED CARCINOGENIC RISK

26th Oct 2005, 18:09 GMT

The proposed protocol is for quantification of excess lifetime cancer risks (lung cancer and mesothelioma) from inhalation exposure to asbestos. The protocol is based on the methods developed by USEPA (1986), but has been updated to include new data that have become available since 1986, and modified to account for the current scientific consensus that cancer risk from asbestos depends both on mineral type and on particle size distribution. In brief, epidemiological exposure-response data for lung cancer and mesothelioma in asbestos workers are combined with estimates of the mineral type(s) and partical size distribution at each exposure location in order to estimate potency factors that are specific to a selected set of mineral type and size "bins".

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