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FeedsFarm.com > Volume 192, number 11: Schistosomiasis and HIV-1 Infection in Rural Zimbabwe: Effect of Treatment of Schistosomiasis on CD4 Cell Count and Plasma HIV-1 RNA Load

Volume 192, number 11: Schistosomiasis and HIV-1 Infection in Rural Zimbabwe: Effect of Treatment of Schistosomiasis on CD4 Cell Count and Plasma HIV-1 RNA Load

3rd Nov 2005, 22:05 GMT

To determine whether treatment of schistosomiasis has an effect on the course of human immunodeficiency virus type 1 (HIV-1) infection, individuals with schistosomiasis and with or without HIV-1 infection were randomized to receive praziquantel treatment at inclusion or after a delay of 3 months; 287 participants were included in the study, and 227 (79%) were followed up. Among the 130 participants who were coinfected, those who received early treatment ([FORMULA]) had a significantly lower increase in plasma HIV-1 RNA load than did those who received delayed treatment ([FORMULA]) ([FORMULA]); this difference was associated with no change in plasma HIV-1 RNA load in the early intervention group ([FORMULA]) and an increase in plasma HIV-1 RNA load in the delayed intervention group ([FORMULA]). Among the 227 participants who were followed up, those who received early treatment ([FORMULA]) had an increase in CD4 cell count, whereas those who received delayed treatment ([FORMULA]) did not ([FORMULA]); this effect did not differ between participants when stratified by HIV-1 infection status ([FORMULA]). The present study suggests that treatment of schistosomiasis can reduce the rate of viral replication and increase CD4 cell count in the coinfected host.

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