MEDAL: Etoricoxib Shows Same Thrombotic Cardiovascular Risk as Diclofenac
14th Nov 2006, 23:44 GMT
Both drugs were similar in effectiveness against arthritis symptoms, but diclofenac was associated with more upper-GI and hepatic events, whereas etoricoxib showed more heart failure and discontinuations due to edema and hypertension. Discussion is focusing on whether diclofenac was the appropriate comparator drug, as it is also believed to carry an increased cardiovascular risk. Heartwire Sue Hughes
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